IJMS, Free Full-Text
Por um escritor misterioso
Descrição
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system (CNS) affecting nearly three million humans worldwide. In MS, cells of an auto-reactive immune system invade the brain and cause neuroinflammation. Neuroinflammation triggers a complex, multi-faceted harmful process not only in the white matter but also in the grey matter of the brain. In the grey matter, neuroinflammation causes synapse dysfunctions. Synapse dysfunctions in MS occur early and independent from white matter demyelination and are likely correlates of cognitive and mental symptoms in MS. Disturbed synapse/glia interactions and elevated neuroinflammatory signals play a central role. Glutamatergic excitotoxic synapse damage emerges as a major mechanism. We review synapse/glia communication under normal conditions and summarize how this communication becomes malfunctional during neuroinflammation in MS. We discuss mechanisms of how disturbed glia/synapse communication can lead to synapse dysfunctions, signaling dysbalance, and neurodegeneration in MS.
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IJMS, Free Full-Text, Autotaxin-LPA-LPP3 Axis in Energy Metabolism and Metabolic Disease, HTML
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IJMS, Free Full-Text
IJMS Free Full-Text Research Advances In Mechanical, 54% OFF
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IJMS, Free Full-Text
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IJMS, Free Full-Text
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Ijms Free Full Text Delayed Onset Of Age Dependent Changes In Ultrastructure Of Myocardial 116100
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IJMS, Free Full-Text
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