Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Por um escritor misterioso
Descrição
Behavioral experiences can modulate neural networks through changes in synaptic morphology and number. In contrast, abnormal morphogenesis of dendritic spines is associated with cognitive impairment, as in Fragile X syndrome. Dendritic or synaptic protein synthesis could provide the specificity and speed necessary for spine morphogenesis. Here, we highlight locally translated proteins shown to affect synaptic morphology (e.g., Fragile X mental retardation protein).
The fragile X mental retardation protein regulates tumor
Altered mRNA transport, docking, and protein translation in
Glial-mediated dysregulation of neurodevelopment in Fragile X
VCP and ATL1 regulate endoplasmic reticulum and protein synthesis
Model showing involvement of FMRP and other FXR proteins (all in
Frontiers The Coordination of Local Translation, Membranous
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse
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