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The role played by alternative splicing in antigenic variability

Por um escritor misterioso

Descrição
Endo-parasites that affect humans include Plasmodium, the causative agent of malaria, which remains one of the leading causes of death in human beings. Despite decades of research, vaccines to this and other endo-parasites remain elusive. This is in part due to the hyper-variability of the parasites surface proteins. Generally these surface proteins are encoded by a large family of genes, with only one being dominantly expressed at certain life stages. Another layer of complexity can be introduced through the alternative splicing of these surface proteins. The resulting isoforms may differ from each other with regard to cell localisation, substrate affinities and functions. They may even differ in structure to the extent that they are no longer recognised by the host’s immune system. In many cases this leads to changes in the N terminus of these proteins. The geographical localisation of endo-parasitic infections around the tropics and the highest incidences of HIV-1 infection in the same areas, adds a further layer of complexity as parasitic infections affect the host immune system resulting in higher HIV infection rates, faster disease progression, and an increase in the severity of infections and complications in HIV diagnosis. This review discusses some examples of parasite surface proteins that are alternatively spliced in trypanosomes, Plasmodium and the parasitic worm Schistosoma as well as what role alternate splicing may play in the interaction between HIV and these endo-parasites.
The role played by alternative splicing in antigenic variability
Defining the genetic and evolutionary architecture of alternative splicing in response to infection
The role played by alternative splicing in antigenic variability
Cells, Free Full-Text
The role played by alternative splicing in antigenic variability
The Function of Pre-mRNA Alternative Splicing in Mammal Spermatogenesis
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The role played by alternative splicing in antigenic variability
The role played by alternative splicing in antigenic variability in human endo-parasites, Parasites & Vectors
The role played by alternative splicing in antigenic variability
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The role played by alternative splicing in antigenic variability
RNA splicing - Wikipedia
The role played by alternative splicing in antigenic variability
The role played by alternative splicing in antigenic variability in human endo-parasites, Parasites & Vectors
The role played by alternative splicing in antigenic variability
The Expanding Landscape of Alternative Splicing Variation in Human Populations - ScienceDirect
The role played by alternative splicing in antigenic variability
Temporal Modulation of Differential Alternative Splicing in HaCaT Human Keratinocyte Cell Line Chronically Exposed to Arsenic for up to 28 Wk, Environmental Health Perspectives
The role played by alternative splicing in antigenic variability
SpliceRCA: in Situ Single-Cell Analysis of mRNA Splicing Variants
The role played by alternative splicing in antigenic variability
Regulatory roles and mechanisms of alternative RNA splicing in adipogenesis and human metabolic health, Cell & Bioscience
The role played by alternative splicing in antigenic variability
PDF) The role played by alternative splicing in antigenic variability in human endo-parasites
The role played by alternative splicing in antigenic variability
Frontiers In silico analysis of alternative splicing events implicated in intracellular trafficking during B-lymphocyte differentiation
The role played by alternative splicing in antigenic variability
PDF) The role played by alternative splicing in antigenic variability in human endo-parasites
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